Tuesday, January 31, 2012

HBT: McLain thinks Tigers' Inge should shut up

Former MVP, Cy Young Award recipient and 31-game winner Denny McLain is a convicted felon and an all-around scumbag. ?But that doesn?t mean he can?t be a funny guy.

McLain was invited to speak at Madonna University in suburban Detroit over the weekend and the subject of the Prince Fielder signing came up. McLain took issue with Brandon Inge?s unhappiness at ? gasp! ? losing the starting third base job to Miguel Cabrera. ?From the Detroit News:

Denny McLain held up an autographed photo of Brandon Inge and showed it to his audience.??This was Brandon Inge?s last photo before he began whining about his playing time,? McLain announced ? McLain held the Inge photo up and tossed it to the floor.??It?s the first time he?s hit something in two years,? McLain said, to more laughter.

OK, that was kind of mean. But it was also kind of funny. Don?t tell me it wasn?t.

That said, I?d rather be Brandon Inge on the worst day of his life than Denny freakin? McLain. Because, let?s face it: it?s way better to be not-so-good at playing baseball than it is to, say, steal millions from pension funds and stuff.

Source: http://hardballtalk.nbcsports.com/2012/01/30/denny-mclain-thinks-brandon-inge-should-shut-up/related/

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Could Florida Be the Knockout Blow for Gingrich? (ContributorNetwork)

In this race for the Republican Party's nomination, things seem to be continuously turning on a dime. Mitt Romney, the well-established front-runner going into the campaign, has been trading the lead with a series of candidates for months now. His most recent -- and likely last -- sparring partner for the nomination is Newt Gingrich, who earlier this month sprinted back into the lead with a solid victory in the South Carolina primary.

But following a strong debate performance last week in Jacksonville, Fla., Romney appears to be taking a commanding lead in Florida polls.

What are the latest polls in Florida indicating?

According to a Rasmussen Reports poll released Sunday, Romney has built a big lead going into Tuesday's primary. The poll, which was conducted Saturday, shows a 16-point lead for Romney. He has 44 percent, while Gingrich is a distance second with 28 percent. Rick Santorum is third with 12 percent and Ron Paul is bringing up the rear with 10 percent. Five percent of respondents were unsure of who they would vote for when they were asked.

A Public Policy Polling survey, which was also conducted Saturday, gave Romney a slimmer lead, 40 percent to 32 percent, over Gingrich. Santorum comes in with 15 percent and Paul has 9 percent of the vote in the poll.

How are the candidates doing nationally?

Given the fact the nomination process involves individual state primaries and caucuses, national polling doesn't hold the same level of importance as each state poll does. That said, there is some hope for Gingrich in a recent national Gallup poll conducted late last week showing he has maintained the gains he has made over Romney following the South Carolina primary. Santorum and Paul remain far down in the poll, as they do in most state polls as well.

After Florida, what will the future hold for the Republican candidates?

The nomination process will speed up. Nevada, Maine, Minnesota and Colorado will vote during the first week in February, with more states to follow later in the month. The race already seems to be down to two candidates -- Romney and Gingrich -- who can realistically win. But Paul has vowed to stay in the race no matter what, and his strategy for collecting delegates in caucus states could prove menacing for Romney and Gingrich.

Santorum's campaign has been stalled since his surprise victory in Iowa. Even if he maintains the funding that he needs to continue into February he shows no signs of gaining traction among voters. The probability that he would drop out of the race by early February, if not sooner, would seem to be high at this point.

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ac/20120131/pl_ac/10900287_could_florida_be_the_knockout_blow_for_gingrich

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Sunday, January 29, 2012

NBC asks Romney to remove Brokaw report on Gingrich ethics violations from paid TV ad (Star Tribune)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/192682945?client_source=feed&format=rss

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Milwaukee's Jackson suspended one game for abusing official (Reuters)

(Reuters) ? Milwaukee Bucks forward Stephen Jackson has been suspended one game for verbally abusing an official and failing to leave the court in a timely manner, the National Basketball Association said on Saturday.

The incident occurred at the end of Milwaukee's 107-100 road loss to the Chicago Bulls on Friday night.

Jackson will serve his suspension on Saturday evening when the Bucks host the Los Angeles Lakers at the Bradley Center.

(Reporting by Mark Lamport-Stokes in San Diego; Editing by Julian Linden)

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/nm/20120128/sp_nm/us_nba_bucks_jackson

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Saturday, January 28, 2012

Too little, too late? Factory jobs making comeback

John Schoen, msnbc.com

Manufacturing accounts for 9 percent of the U.S. workforce, compared with 28 percent in 1960 and 12 percent just a decade ago.

By Allison Linn

President Barack Obama is on the road this week touting a plan to bring jobs back to the United States, in part by bolstering manufacturing here.

It?s no secret that?s a tough challenge.

The United States has lately seen an increase in manufacturing jobs, something Obama noted in his State of the Union address Tuesday. According to the Bureau of Labor Statistics, about 330,000 manufacturing jobs have been created over the past two years, bringing the total to nearly 11.8 million as of December.

Still, that is a nearly 2 million short of the?13.7 million manufacturing jobs that existed when the economy went into recession in December 2007. And it?s far fewer than in the late 1970s, when more than 19 million Americans -- out of a much smaller work force -- were employed in manufacturing, which was?seen as a key path to a middle-class life.

Manufacturing may be bouncing back, but it is returning in a far different form.?The recession washed out many inefficent companies, leaving behind?operations that even leaner and more highly automated. That means they can make do?with?fewer workers even as they increase production.

As a recent series of stories in The New York Times has highlighted, successful companies like Apple have prospered largely by mastering a global supply chain that depends on sending work overseas to take advantage of low-cost labor.

Obama is hoping that tax breaks and other incentives will help encourage manufacturers to keep jobs here, or even bring some back. Time will tell whether that is true.

Related:

Why companies aren?t hiring more workers

Yes, we do still make things in America

Apple accused of ignoring labor abuses

Source: http://lifeinc.today.msnbc.msn.com/_news/2012/01/27/10245636-too-little-too-late-factory-jobs-making-comeback

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Friday, January 27, 2012

Rift MMO launches Android app with in-game items

Rift app for Android

Massively multiplayer game Rift has just launched its first companion app for Android. Not only does it have the usual stuff like chat with in-game friends and event notifications, they've also included mini-games through which you can win proper in-game items. 

While World of Warcraft still claims the throne of high fantasy online roleplaying games, I've seen a lot of WoW veterans switch guys and get involved with Rift. Although I haven't played it myself, it seems like Rift offers a lot more in terms of class customizability, and the art style seems to err more on the side of realism rather than cartoony chariactures. Otherwise, it's very much the same sort of stuff - world-spanning player-versus-player combat, cooperative raids, friend-packed guilds, and seasonal events. 

World of Warcraft also has mobile app, but they're kind of jerks for tacking on an extra $3 to your subscription fee if you want to make use of them. It's good to see Rift isn't making such a shameless moneygrab, and are more interested in winning the goodwill of their players before pouncing on their credit card. 

If you're interested in giving Rift a shot, you can download the free week-long trial over here. After that, you'll need to shell out $12/month to keep playing. Hopefully the guys at Rift will be able to add some item database and character look-up features in the future, but in the meantime, you can download Rift Mobile for Android below in the Market. 

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/45ZSBD7aFnQ/story01.htm

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Associates of Megaupload boss Kim Dotcom granted bail

By msnbc.com news services

A New Zealand court granted bail on Thursday to two associates of the founder of online file-sharing website Megaupload, accused of being involved in a scheme that allegedly made more than $175 million from Internet piracy and illegal file sharing.

Dutchman Bram van der Kolk, 29, and Finn Batato, a 38-year-old German, who were arrested last Friday along with Megaupload's founder, Kim Dotcom, were freed on bail. A decision on another accused, Mathias Ortman, was put off until Friday pending further submissions on his bail application.

As Kim Dotcom appeared in a New Zealand court Monday morning, new details emerged about his extravagant lifestyle. NBC's Stephanie Gosk reports.



"I am satisfied that the risk of flight here is minimal and such risk as remains can be met by the imposition of strict bail conditions including electronic monitoring," Judge David McNaughton said in a written judgement.

A lawyer for the men had argued their role in the company was different from that of Dotcom, and they did not have secret sources of funds or multiple identities.

The United States wants to extradite all four on charges of Internet piracy, copyright infringement, racketeering and money laundering.

Dotcom, 38, was refused bail on Wednesday because the judge believed there was a significant risk he could try to flee New Zealand. He will reappear in court on Feb. 22. His lawyer is preparing to appeal that decision, maintaining that Dotcom does not have the means to leave the country.

The defendants have said they are innocent of the piracy and other charges, asserting the company simply offered online storage.

Nigel Marple / Reuters

An aerial view of the Dotcom Mansion, home of accused Kim Dotcom, who founded the Megaupload.com site and ran it from the $30 million mansion in Coatesville, Auckland.

An extradition application must be lodged within 45 days of an arrest, and the U.S. must show the alleged offences would be crimes in New Zealand punishable by at least 12 months in jail.

Legal experts have said the extradition process is likely to be long and complex.

A U.S. Justice Department official told The Associated Press a sixth suspect, Sven Echternach, has been located in Germany, but declined to say if he'd been arrested.

Reuters and the Associated Press contributed to this report.

Source: http://worldnews.msnbc.msn.com/_news/2012/01/26/10242551-associates-of-megaupload-boss-kit-dotcom-granted-bail

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Thursday, January 26, 2012

Greece, creditors edge closer to deal (Reuters)

ATHENS (Reuters) ? Greece and its private creditors made progress on Thursday in talks on restructuring its debt, both sides said, and they will continue negotiating on Friday with the aim of sealing an agreement within a few days.

Athens needs a deal quickly to avert a chaotic default when a major bond redemption comes due in March. Greece's creditors are demanding that the European Central Bank contribute to a deal to put the country's messy finances back on track.

"The talks focused on legal and technical issues and progress was made. They will continue on Friday and probably on Saturday too," a senior Greek government official told Reuters on condition of anonymity.

"We aim to conclude the deal very soon."

The Institute of International Finance, which leads talks on behalf of creditors, similarly cited progress and said work would continue Friday. Neither side disclosed any details.

After weeks of wrangling over the coupon, or interest rate, Greece must pay on new bonds it will swap for existing debt, attention has shifted to whether the ECB and other public creditors will follow private bondholders in swallowing losses.

A day after International Monetary Fund chief Christine Lagarde said the ECB may need to accept losses on its Greek holdings, the European Union's top economic official also warned more public money will be needed to make up a shortfall in the country's second bailout.

EU Economic and Monetary Affairs Commissioner Olli Rehn told Reuters "there is likely to be some increased need of official sector funding, but not anything dramatic." It was the first time a top EU official had said more public money than a planned 130 billion euro package would be required to rescue Greece.

Private bondholders have added to the pressure by insisting that others who bought bonds, and in particular the ECB, which is Athens' single biggest creditor, take part in the bond swap.

The swap, also known as the Private Sector Involvement, is aimed at slashing Greece's debt by getting creditors to write down their holdings by 50 percent nominally. Real losses are expected to be higher, depending on the terms involved.

"It would be outrageous if the ECB doesn't take part in the PSI as keeping their Greek bonds to maturity would allow them to make a profit, while everybody else is taking 70 percent (losses) or even more," one source close to the talks said.

The IIF wants public sector officials to be more decisive in negotiations over Greek debt, the bank lobby group's chairman and Deutsche Bank CEO Josef Ackermann told CNBC.

The ECB, which owns roughly 40 billion euros worth of Greek bonds, is no closer to agreeing on whether or not it will take losses on the Greek bonds it owns after a late night Wednesday meeting, euro zone central bank sources told Reuters.

Either way, a debt deal at the very latest must be clinched a month before 14.5 billion euros of bond redemptions fall due on March 20, the first source said, i.e., in just over three weeks.

If a deal is not reached by then, Greece could sink into an uncontrolled default that would trigger a banking crisis spreading contagion through the euro zone, though the ECB's creation of nearly half a trillion euros of three-year money for the banks in December has tempered that fear.

Debt-laden Italy saw its government bond yields and the cost of insuring against a default fall on Thursday, helped by solid demand for short-term debt at an auction.

COUPON STUMBLE

So far the coupon on the new bonds had been the main stumbling block in the negotiations.

On Monday, euro zone ministers rejected the creditors' offer of a 4 percent coupon on new bonds after Greece and its EU/IMF lenders held out for a 3.5 percent interest rate. They want the lower coupon to ensure the country's debt falls to a target of 120 percent of GDP by 2020, from around 160 percent now.

A second source familiar with the negotiations said the "coupon is parked for current time until we can get closer on detail of the overall package". Asked if that would include the ECB, the source said: "We would expect it to, still to be determined though."

Greek bankers and government officials said they had not heard of any new proposal from creditors, after local media reported they were willing to improve their "final offer" of a 4 percent interest rate on the new bonds to about 3.75 percent.

One Greek daily, Kerdos, said participation of public sector creditors including the ECB in the swap deal was a pre-condition for that offer.

"Until last week, we knew that the steering committee was authorized to concede up to 3.8 percent for the average coupon," one senior Greek banker told Reuters.

"But things are once again up in the air. You have to deal with politicians and 15 different governments asking for different things."

Exact details of Friday's meetings have yet to be scheduled, after IIF chief Charles Dallara left a meeting with Prime Minister Lucas Papademos late on Thursday.

Earlier, German Chancellor Angela Merkel said the debt swap talks were on a "good path".

Senior EU, IMF and ECB officials are holding talks with the Greek government in parallel with the debt swap talks, to flesh out a new 130-billion euro bailout for Greece. They have warned they need the debt swap to cut Greece's debt substantially in order to go ahead with the new loans.

Talks with the "troika" inspectors on the new bailout program are expected to go well into next week.

A senior German official said Greece was not expected to play a major role at the EU leaders summit on Monday and that Germany does not expect the troika to deliver a report on Greece's progress before the summit.

Greece has made little progress on reforms as it stumbles through its worst post-World War II economic crisis. The task facing the country has been made harder with anger against austerity measures and squabbling politicians running high.

A poll on Thursday showed Greece's conservatives had widened their lead over socialist coalition partners ahead of elections expected in April, but they would not win an absolute majority if elections were held now.

Eurogroup chairman Jean-Claude Juncker was quoted in a German newspaper as saying the euro zone would probably have to support Greece longer than expected -- more than 10 years.

(Additional reporting by Sarah White and Sophie Sassard in London, Paul Taylor and Axel Threlfall in Davos, Harry Papachristou, Tatiana Fragou, Renee Maltezou and Karolina Tagaris in Athens; Writing by Deepa Babington; Editing by Dan Grebler)

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20120126/bs_nm/us_greece

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Roche plans a tender offer for Illumina

Swiss drugmaker Roche plans to offer $5.7 billion for diagnostics company Illumina in a deal it says would accelerate routine clinical use of DNA testing.

Roche Holding AG said Wednesday buying Illumina Inc., which has rebuffed it, will strengthen its position in diagnostics because the companies' technologies are complementary.

Illumina's board Wednesday urged shareholders not to take action until it reviews the proposal and makes a recommendation.

The news sent Illumina's shares up 43 percent, or $16.27, to $53.95 in midday trading, well above the offer of $44.50 per share, implying that shareholders expect Roche to raise its price.

Roche's bid represents an 18 percent premium over Tuesday's closing price of $37.69 for Illumina shares. It's 64 percent higher than the last closing price before rumors surfaced in December that Roche was considering acquiring Illumina. That speculation boosted Illumina's stock price, but the shares have still lost about half of their value over the last 12 months.

Illumina, based in San Diego, makes systems that analyze an individual's DNA. It's expected that future breakthroughs will use that information to tailor treatments in ways that are especially effective for people with certain genes.

Roche, which has more than 80,000 employees and specializes in cancer diagnosis and diabetes management, said it has tried to negotiate a deal, but Illumina has declined to participate. Roche plans to nominate a slate of independent candidates for a majority of the seats on Illumina's board of directors and to propose measures for shareholders to consider at their 2012 annual meeting.

Roche has a history of success with hostile offers. It eventually acquired U.S. cancer drug maker Genentech in 2009 by forcing buyout talks with such an approach.

Credit Suisse analyst Vamil Divan said Illumina is the biggest gene sequencing company, with a market share of about 65 percent. Roche is a distant third with a share of about 15 percent, he said, behind Life Technologies Corp.

"Roche is the global leader in clinical diagnostics and would likely be able to accelerate the move of sequencing from the research setting to the clinical arena," Divan wrote in a research note.

Divan said it would make sense for Roche to buy Illumina, but noted that the price was "very low" and that Illumina shareholders who bought the stock last summer when it traded above $70 may be reluctant to sell for $44.50. He said Roche may have to raise its offer to around $60 per share to close the sale.

Illumina and Life Technologies are both getting ready to sell systems that can sequence a person's entire genome in about a day. Earlier this month, Illumina said it plans to start launch the HiSeq 2500 system in the second half of the year, and said the system can sequence a genome in 27 hours.

Life Technologies is planning to ask the Food and Drug Administration to approve its Ion Proton Sequencer this year. The Carlsbad, Calif., company said the Ion Proton will cost about $149,000 and will be able to sequence an individual genome for $1,000. It said older sequencing costs $5,000 to $10,000 and takes weeks or months. Illumina has not announced a price for the HiSeq 2500.

Roche CEO Severin Schwan said the company remains open to talking with Illumina and developing a joint strategy for the combined businesses. The deal will depend on a majority of Illumina shareholders tendering their stock, although Roche has yet to commence its offer.

If the buyout succeeds, Roche plans to move the headquarters for its applied science business to San Diego but maintain operations for the unit in Penzberg, Germany, where it's now based.

Roche Chairman Franz Humer said in a letter to Illumina President and CEO Jay Flatley that Roche hopes to retain Illumina's managers and employees. The company employs about 2,100 workers, according to FactSet.

Illumina's board confirmed last week that it wasn't interested in negotiating a deal, according to Humer's letter. It is scheduled to announce its fourth-quarter results and hold a conference call with investors on Tuesday.

Associated Press

Source: http://hosted2.ap.org/apdefault/f70471f764144b2fab526d39972d37b3/Article_2012-01-25-Roche-Illumina/id-c3d2413bb2934278938931616aef2247

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Wednesday, January 25, 2012

Adult stem cells could improve angioplasy outcome; Study to explore usage

ScienceDaily (Jan. 23, 2012) ? A Creighton University School of Medicine researcher has received a $3.3 million, five-year grant from the National Institutes of Health to study what role adult stem cells might play in repairing damaged coronary arteries, a complication that often occurs in patients after they undergo angioplasty and stenting.

"Restenosis, a re-narrowing of coronary arteries in the heart, after balloon angioplasty and the placement of stents, is a serious problem. Drug-eluting stents can help reduce the occurrence of restenosis. However, there is a serious tradeoff.

Drug-eluting stents can lead to thrombosis (platelet deposits in the endothelial lining around the blood vessels that destroy the lining), which then requires longer periods of anti-platelet therapy. This therapy, in turn, can produce serious side effects, including nosebleed, upset stomach, nausea and diarrhea," said Devendra Agrawal, Ph.D., principal investigator and a professor of biomedical sciences, internal medicine and medical microbiology and immunology.

For the study, Agrawal and his co-investigators, Creighton cardiologist Michael Del Core and pathologist William Hunter will deliver adult stem cells (autologous mesenchymal stem cells), together with a novel gene, at the site of an interventional procedure in the coronary arteries of a pig model.

The goal is to determine whether the administration of adult stem cells, along with the gene therapy, is superior to using drug-eluting stents following angioplasty, said Agrawal, holder of The Peekie Nash Carpenter Endowed Chair in Medicine. If successful, he added, the treatment could even eliminate the need for stents.

Recent research has shown that angioplasty and stenting -- commonly used to open narrowed coronary arteries -- are not as effective as once thought.

In fact, a study involving more than 15,000 patients and published Nov. 28 online by the Archives of Internal Medicine, shows that it can even do more harm than good in some patients. According to the study, nearly one in 10 patients undergoing coronary angioplasty was readmitted to a hospital within 30 days, and these patients were at higher risk of death within one year.

With angioplasty, a catheter-guided balloon is inserted to open a narrowed coronary artery. A wire mesh stent is typically implanted during the procedure to keep the artery open.

Eleven to18 percent of all patients experience restenosis or a re-narrowing of the artery within three-four years, said Agrawal.

This is the second grant Agrawal has received in recent months to explore alternatives to stenting. The first grant totaled $2.58 million over four years.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/qqln8tgBLlM/120123133644.htm

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Tuesday, January 24, 2012

Self-collection and HPV DNA testing could be an effective cervical cancer screening

Self-collection and HPV DNA testing could be an effective cervical cancer screening [ Back to EurekAlert! ] Public release date: 23-Jan-2012
[ | E-mail | Share Share ]

Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute

Human papillomavirus (HPV) testing of self-collected specimens may be a more effective way to screen for cervical cancer in low-resource settings compared to visual inspection with acetic acid (VIA) and liquid-based cytology (LBC), according to a study published January 23 in the Journal of the National Cancer Institute.

Cervical cancer is the third most common cancer found in women with approximately 530,000 new cases each year resulting in an estimated 275,000 deaths. In developed countries, cervical cancer incidences have declined, mostly due to cervical cytology screening campaigns, which requires significant medical resources and laboratory infrastructure. Cervical cancer is on the rise in the developing world, with one-seventh of the world's cervical cancer cases in China, where there is no nationwide screening program for the disease yet. There, researchers have proposed that HPV testing of self-collected Pap specimens might serve as an alternative or complementary method of primary cervical cancer screening method.

In order to determine the effectiveness of HPV testing of self-collected Pap specimens (termed "Self-HPV testing" in the report), Professor You-Lin Qiao, M.D., Ph.D., of the Cancer Institute/Hospital at the Chinese Academy of Medical Sciences/Peking Union Medical College and colleagues, assembled individual patient data from five population-based cervical cancer-screening studies in China from 1999-2007, in which participants received HPV testing of self-collected Pap specimens, HPV testing of physician-collected Pap specimens, LBC, and VIA. The researchers then analyzed the pooled data to detect biopsy-confirmed cervical intraepithelial neoplasia grade 2 or more severe (CIN2+) or CIN3+. Of the 13,140 rural Chinese women screened for cervical cancer, 507 were diagnosed with CIN2+, 273 with CIN3+, and 37 with cervical cancer.

The researchers found that HPV testing of self-collected Pap specimens was more sensitive and less specific than VIA and LBC but less sensitive and similarly specific compared to physician-collected Pap specimens. They conclude that self-collection with HPV testing could help expand China's current screening outreach. "Although it is not specific enough to be a stand-alone test, self-HPV testing provides sensitive results without pelvic exams, medical professionals, or health-care facilities and thus has the potential to serve as a primary cervical cancer screening method for women, regardless of their geographic location or access to health care," the researchers write. Self-sampling procedures were instructed by medical professionals, and it is unclear whether unsupervised self-examinations would give out similar outcomes. Still, the researchers write, "The incorporation of Self-HPV testing in the Chinese government's planning of a national cervical cancer screening program would complement the current program by increasing its coverage of unscreened populations."

In an accompanying editorial, Patrick Petignat, M.D., of the University Hospitals of Geneva, writes that while HPV Self-Sampling for primary cervical cancer screening may help increase the number of women being screened, introducing a new screening method should be met with caution. He feels that determining both the cost effectiveness of the procedure as well as women's personal willingness to undergo self-screening is essential; furthermore, patients need to be properly educated about self-screening. "Efforts are still needed to increase awareness about HPV and cervical cancer, and more information is needed about the reliability of the method," Petignat writes. "Health-care professionals should provide sufficient support to participants to properly interpret their test results, thus avoiding any delay to follow-up and treatment."

###

Contact:

Article: You-Lin Qiao, qiaoy@cicams.ac.cn

Editorial: Patrick Petignat, patrick.petignat@hcuge.ch



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Self-collection and HPV DNA testing could be an effective cervical cancer screening [ Back to EurekAlert! ] Public release date: 23-Jan-2012
[ | E-mail | Share Share ]

Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute

Human papillomavirus (HPV) testing of self-collected specimens may be a more effective way to screen for cervical cancer in low-resource settings compared to visual inspection with acetic acid (VIA) and liquid-based cytology (LBC), according to a study published January 23 in the Journal of the National Cancer Institute.

Cervical cancer is the third most common cancer found in women with approximately 530,000 new cases each year resulting in an estimated 275,000 deaths. In developed countries, cervical cancer incidences have declined, mostly due to cervical cytology screening campaigns, which requires significant medical resources and laboratory infrastructure. Cervical cancer is on the rise in the developing world, with one-seventh of the world's cervical cancer cases in China, where there is no nationwide screening program for the disease yet. There, researchers have proposed that HPV testing of self-collected Pap specimens might serve as an alternative or complementary method of primary cervical cancer screening method.

In order to determine the effectiveness of HPV testing of self-collected Pap specimens (termed "Self-HPV testing" in the report), Professor You-Lin Qiao, M.D., Ph.D., of the Cancer Institute/Hospital at the Chinese Academy of Medical Sciences/Peking Union Medical College and colleagues, assembled individual patient data from five population-based cervical cancer-screening studies in China from 1999-2007, in which participants received HPV testing of self-collected Pap specimens, HPV testing of physician-collected Pap specimens, LBC, and VIA. The researchers then analyzed the pooled data to detect biopsy-confirmed cervical intraepithelial neoplasia grade 2 or more severe (CIN2+) or CIN3+. Of the 13,140 rural Chinese women screened for cervical cancer, 507 were diagnosed with CIN2+, 273 with CIN3+, and 37 with cervical cancer.

The researchers found that HPV testing of self-collected Pap specimens was more sensitive and less specific than VIA and LBC but less sensitive and similarly specific compared to physician-collected Pap specimens. They conclude that self-collection with HPV testing could help expand China's current screening outreach. "Although it is not specific enough to be a stand-alone test, self-HPV testing provides sensitive results without pelvic exams, medical professionals, or health-care facilities and thus has the potential to serve as a primary cervical cancer screening method for women, regardless of their geographic location or access to health care," the researchers write. Self-sampling procedures were instructed by medical professionals, and it is unclear whether unsupervised self-examinations would give out similar outcomes. Still, the researchers write, "The incorporation of Self-HPV testing in the Chinese government's planning of a national cervical cancer screening program would complement the current program by increasing its coverage of unscreened populations."

In an accompanying editorial, Patrick Petignat, M.D., of the University Hospitals of Geneva, writes that while HPV Self-Sampling for primary cervical cancer screening may help increase the number of women being screened, introducing a new screening method should be met with caution. He feels that determining both the cost effectiveness of the procedure as well as women's personal willingness to undergo self-screening is essential; furthermore, patients need to be properly educated about self-screening. "Efforts are still needed to increase awareness about HPV and cervical cancer, and more information is needed about the reliability of the method," Petignat writes. "Health-care professionals should provide sufficient support to participants to properly interpret their test results, thus avoiding any delay to follow-up and treatment."

###

Contact:

Article: You-Lin Qiao, qiaoy@cicams.ac.cn

Editorial: Patrick Petignat, patrick.petignat@hcuge.ch



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Source: http://www.eurekalert.org/pub_releases/2012-01/jotn-sah011912.php

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Man Publishes Father-In-Law's Entire Life One Picture At a Time [Photography]

The late Nick DeWolf—a MIT engineer who designed more than 300 semiconductor and electronic systems—really loved photography. So much that he carried a camera for most of his life. Now his son-in-law is digitizing all his pictures and publishing them one by one. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/jwI_JuTHJrk/

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Monday, January 23, 2012

HealthLawProf Blog: Lombardo on Legal Archaeology

? Worth Reading This Week | Main | Health Law Headlines of the Week (1/15-1/21) ?

January 21, 2012

Lombardo on Legal Archaeology

Paul A. Lombardo published an essay "Legal Archaeology: Recovering the Stories behind the Cases" in the Fall 2008 issue of the Journal of Law, Medicine, and Ethics. ?It reminded me of the wonderful chapters in this volume of "health law stories." ?Here are some excerpts that may be of interest:?

?Every lawsuit is a potential drama: a story of conflict, often with victims and villains, leading to justice done or denied. Yet a great deal, if not all, that we learn about the most noteworthy of lawsuits ? the truly great cases ? comes from reading the opinion of an appellate court, written by a judge who never saw the parties of the case, who worked at a time and a place far removed from the events that gave rise to litigation.

Rarely do we admit that the official factual account contained in an appellate opinion may have only the most tenuous relationship to the events that actually led the parties to court. The complex stories ? turning on small facts, seemingly trivial circumstances, and inter-contingent events ? fade away as the ?case? takes on a life of its own as it leaves the court of appeals.

How can a law professor correct this bias? ?Here are some of Lombardo's suggestions:?

The best starting point for doing legal archaeology is the case record itself. We all begin our investigation of cases by reading an appellate opinion. With some extra effort, we can retrieve the records and briefs that the judges relied on as they wrote that opinion. Of course, the case record that is printed for submission to an appellate tribunal will include only a small portion of the documents that make up the lawsuit?s paper trail.

Much of the material contained in the case record is now filed electronically, and for recent cases, may be available on the Web. But even for most pre-Internet cases, finding the proper repository for all these records is not difficult. A visit to your school?s reference librarian with copies of the articles referenced here should get you started.

Lombardo also suggests consulting newspapers and magazines, professional journals, and material generated by the parties and their lawyers. ?Though some students may complain of "reading overload," skillful editing can make the effort to contextualize the cases well worth everyone's while. ?I also anticipate that internet archives of particular helpful case studies will accumulate over time.

Selected References from Lombardo

P. Brooks and P. Gewirtz, eds., Law?s Stories: Narrative and Rhetoric in the Law (New Haven: Yale University Press, 1997).

J. L. Maute, ?The Value of Legal Archaeology,? Utah Law Review 2000, no. 2 (2000).

D. L. Threedy, ?Legal Archaeology: Excavating Cases, Reconstructing Context,? Tulane Law Review 80, no. 4 (2006)

C. Geertz, ?Thick Description: Toward an Interpretive Theory of Culture,? in The Interpretation of Cultures: Selected Essays.

[FP]

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Memo scandal witness refuses to travel to Pakistan

Akram Sheikh, lawyer of Mansoor Ijaz addressing a news conference outside the Supreme Court in Islamabad, Pakistan on Monday, Jan. 23, 2012. The chief witness in a secret memo scandal Mansoor Ijaz threatens to bring down the president will not travel to Pakistan to testify, claiming the government has set a trap to prevent him from leaving, his lawyer said Monday. (AP Photo/B.K.Bangash)

Akram Sheikh, lawyer of Mansoor Ijaz addressing a news conference outside the Supreme Court in Islamabad, Pakistan on Monday, Jan. 23, 2012. The chief witness in a secret memo scandal Mansoor Ijaz threatens to bring down the president will not travel to Pakistan to testify, claiming the government has set a trap to prevent him from leaving, his lawyer said Monday. (AP Photo/B.K.Bangash)

Akram Sheikh, lawyer of Mansoor Ijaz addresses a news conference outside the Supreme Court in Islamabad, Pakistan on Monday, Jan. 23, 2012. The chief witness in a secret memo scandal Mansoor Ijaz threatens to bring down the president will not travel to Pakistan to testify, claiming the government has set a trap to prevent him from leaving, his lawyer said Monday. (AP Photo/B.K.Bangash)

(AP) ? The chief witness in a secret memo scandal that threatens to bring down the president will not travel to Pakistan to testify, claiming the government has set a trap to prevent him from leaving, his lawyer said Monday.

Mansoor Ijaz offered to record his testimony and submit it to a Supreme Court commission that is investigating the scandal, said lawyer Akram Sheikh. Ijaz, a U.S. businessman of Pakistani origin, was scheduled to travel to Pakistan to appear before the commission on Tuesday but had bickered with the government over who would guarantee his safety.

Ijaz has accused the Pakistani government of orchestrating a memo, which he delivered to the U.S. last year, asking Washington to help stop a supposed military coup following the American raid that killed Osama bin Laden. The Pakistani government has denied any involvement.

The army was outraged by the memo and denied it ever intended to carry out a coup. It successfully pushed the Supreme Court to investigate against the wishes of the government, which said the matter was already being probed by the parliament.

Ijaz has claimed the Supreme Court commission ordered the military to guarantee his security while in Pakistan, but the government has said the job was the responsibility of the Interior Ministry. Interior Minister Rehman Malik has warned Ijaz could be prevented from leaving the country if requested by the parliamentary committee probing the scandal.

"It seems like a well-orchestrated trap to hold Mansoor Ijaz indefinitely in Pakistan," said Sheikh, his lawyer.

Ijaz has accused the former Pakistani ambassador to the U.S., Husain Haqqani, of crafting the memo with the support of President Asif Ali Zardari. Both men have denied any connection to the memo, although Haqqani resigned in the wake of the scandal. The Supreme Court has prevented the former envoy from leaving the country while it is investigating the scandal.

Some observers have questioned Ijaz's credibility. Those questions increased last week after a music video surfaced in which Ijaz acted as a commentator for a female wrestling match in which both women eventually ripped off their bikinis. Ijaz claimed he didn't know there would be nudity in the video.

One of the reasons the memo scandal has generated so much controversy is the rampant anti-American sentiment in Pakistan. The memo offered to replace Pakistan's national security leadership with people favorable to the U.S. in return for help from Washington in stopping the supposed coup.

The U.S. has provided Pakistan with billions of dollars over the past decade to help fight the Taliban and al-Qaida, but relations have always been defined by a lack of trust.

The raid that killed bin Laden in Pakistani garrison town heightened mistrust between the two countries. Pakistan was outraged it was not told about the operation beforehand, and U.S. officials questioned how bin Laden was able to live near Pakistan's equivalent of West Point for years.

The relationship deteriorated further at the end of last year when American airstrikes accidentally killed 24 Pakistani soldiers at two posts along the Afghan border. Pakistan retaliated by closing its border crossings to supplies meant for NATO troops in Afghanistan and kicking the U.S. out of a base used by American drones.

Drone strikes have been a source of tension between the two countries because they are widely perceived in Pakistan as mostly killing civilians, a claim denied by the U.S. The U.S. held off on carrying out drone attacks in Pakistan for over six weeks after the 24 Pakistani soldiers were killed on Nov. 26.

But the strikes have since resumed. A U.S. drone fired missiles at a house and a vehicle in northwestern Pakistan on Monday, killing four alleged militants in an attack that could signal the program is again picking up steam.

The U.S. had recommenced strikes on Jan. 10, when missiles hit a house in the North Waziristan tribal area in an attack that American officials said killed a key al-Qaida operations planner, Aslam Awan. The U.S. carried out another attack two days later.

Monday's strike in North Waziristan's Deegan village was the third since the attacks resumed. Initial reports indicated the alleged militants killed were foreigners, said Pakistani intelligence officials, speaking on condition of anonymity because they were not authorized to talk to the media.

The U.S. refuses to speak publicly about the CIA-run drone program in Pakistan, but American officials have said privately that the strikes have killed many senior Taliban and al-Qaida commanders.

Although Pakistan is widely believed to have supported the strikes in the past, that cooperation has become strained as the relationship between the two countries has deteriorated.

____

Associated Press writer Rasool Dawar contributed to this report from Dera Ismail Khan, Pakistan.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-01-23-AS-Pakistan/id-b9976ff9a57449628767080c6ab9d192

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Sunday, January 22, 2012

Watch the Milky Way spin in space

By Alan Boyle

The International Space Station's crew has been sending down tons of stunning imagery of the planet below, but the main appeal of this video goes in a different direction ? toward the gorgeous galaxy right above our heads.

The time-lapse video is based on pictures taken on Dec. 29 while the space station sailed high above Africa, crossing over to the South Indian Ocean. You can make out the flashes of lightning storms, and if you look very closely you can see the long streak of Comet Lovejoy against the backdrop of the Milky Way. The best frame for seeing the comet comes around the 12-second mark in the 23-second clip displayed above. If you need help spotting it, play this YouTube alternative. Here's the HD version from NASA.

To see the latest and greatest time-lapse and still imagery from the International Space Station's vantage point, check out NASA's Gateway to Astronaut Photography of Earth (and particularly the video page). For still more, you'll want to keep tabs on the Fragile Oasis Facebook page as well as NASA astronaut Ron Garan's Google+ page.

More views of Earth from space:


Tip o' the Log to Jason Major, who watches over Lights in the Dark.

Alan Boyle is msnbc.com's science editor. Connect with the Cosmic Log community by "liking" the log's Facebook page, following @b0yle on Twitter or adding Cosmic Log's Google+ page to your circle. You can also check out "The Case for Pluto," my book about the controversial dwarf planet and the search for other worlds.

Source: http://photoblog.msnbc.msn.com/_news/2012/01/19/10193864-watch-the-milky-way-spin

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Saturday, January 21, 2012

Malawi leader: Women can dress as they wish (AP)

BLANTYRE, Malawi ? A spate of recent attacks on women wearing pants and miniskirts has prompted Malawi's president to declare on national television that women have the right to choose their dress.

President Bingu wa Mutharika also denied Thursday that he ordered street children and vendors to attack women, who have been stripped of their pants and short skirts.

The president says, "Every woman and girl has the right to dress the way they wish."

That hasn't always been so. During the 1963-1994 dictatorship of the late Hastings Kamuzu Banda, women in Malawi were banned from wearing trousers. Banda's "indecency in dress" laws were repealed when democracy came in 1994.

Women's rights activists plan to wear pants during a protest march Friday.

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/ap/20120119/ap_on_re_af/af_malawi_women_s_dress

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Iran lawmaker: Obama sent secret letter to Ayatollah

By msnbc.com news services

An Iranian lawmaker claimed Wednesday that President?Barack Obama called for direct talks with Iran in a secret letter to the Islamic Republic's supreme leader that also warned Tehran against closing the strategic Strait of Hormuz.

Obama administration officials denied to The Associated Press there was such a letter.

Iran has threatened to close the waterway, the route for about one-sixth of the global oil flow, because of new U.S. sanctions over its nuclear program.

Conservative lawmaker Ali Motahari revealed the content of the purported letter days after the Obama administration said it was warning Iran through public and private channels against any action that threatens the flow of oil from the Persian Gulf.

"In the letter, Obama called for direct talks with Iran," the semiofficial Fars news agency quoted Motahari as saying Wednesday. "The letter also said that closing the Strait of Hormuz is (Washington's) red line."

"The first part of the letter contains threats and the second part contains an offer for dialogue," he added.

Iran's Foreign Ministry spokesman Ramin Mehmanparast confirmed that Tehran received the letter and was considering a possible response.

In Washington, an Obama administration official denied that Obama sent a letter to Ayatollah Ali Khamanei, saying communication of U.S. views were being delivered through other diplomatic messages. The official spoke on condition of anonymity because of the sensitivity of the issue.

U.S. forces are?fully prepared to deal with any Iranian threats?to close the Strait of Hormuz, Defense Secretary Leon Panetta said on Wednesday.

"We are not (taking) any special steps at this point in order to deal with the situation,'' Panetta told reporters at the Pentagon, Reuters reported. "Why? Because frankly we are fully prepared to deal with that situation now.''

The Associated Press and Reuters contributed to this report.

More from msnbc.com and NBC News:

Source: http://worldnews.msnbc.msn.com/_news/2012/01/18/10183146-iran-lawmaker-obama-sent-secret-letter-to-ayatollah

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Friday, January 20, 2012

Ratings king 'American Idol' ready for 11th season

(AP) ? "American Idol" is having a bit of a Goldilocks moment.

When the nation's favorite TV addiction debuted 10 years ago, critics complained the judges were too mean to the hordes of would-be singers seeking celebrity.

But after pop icons Jennifer Lopez and Steven Tyler became judges last year, some fans complained the show had lost its bite. "American Idol," critics complained, had become too nice.

Now in its 11th season, the Fox show that spawned a dozen pop stars and copycat talent competitions is hoping to get it just right.

With the second post-Simon Cowell season under way, Lopez and Tyler said they are striking a balance between showing compassion and respect for their fellow artists, while also not mincing their words.

"Last year was kind of our first year and we were kind of finding our way and figuring out how we were going to do things," Lopez said during a press conference in between filming the show in Las Vegas on Wednesday, hours before the Season 11 premiere. "But I just think we are more to the point now. We understand how to do it."

Tyler joked that he was peppering his encouragement with "well-rounded, slanderous attacks."

Tyler and Lopez's still-evolving shtick will likely determine whether "Idol" can match its previous successes. In an era of social networking, where YouTube videos result in record contracts, does America still want pop stars invented by a TV show?

All signs say yes.

It's been a decade since Texas native Kelly Clarkson was plucked from obscurity and turned into the nation's first American Idol in 2002 and by all accounts the show has retained its dominance over the nation's TV viewers.

Lopez and Tyler's debut year saw the show maintain its spot as the nation's most-watched TV show, making it No. 1 for the eighth-straight season. Scotty McCreery, last season's winner, became the first "Idol" to start his post-show career with a No. 1 album since Ruben Studdard in 2003.

No major changes have been announced for the show's 11th season. The season is opening with taped audition episodes before it shifts to live shows in Los Angeles that include audience voting. The show's season premier Wednesday was to focus on Savannah, Georgia, before continuing in Pittsburgh on Thursday.

Veteran music producer Jimmy Iovine, chairman of Interscope-Geffen-A&M, is returning as the in-house mentor for the contestants. Finalists will once again compete midway through the competition on the Las Vegas Strip, where 42 contestants practiced singing Wednesday morning.

Tyler said soul music has emerged has this season's genre of choice, with many of the contestants looking to channel chart-topper and British soul diva Adele.

The season could mark Ryan Seacrest's last year hosting the show. He has said he would like to stay on as the show's host past 2012, but his contract ends this year. There have been several reports that Seacrest could replace Matt Lauer, should he decide to leave the "Today" show on NBC.

Season 11 opens in a different era from when the show launched in 2002. Then, former judge Cowell helped turn the competition into a national phenomenon with his harsh feedback for the show's less-than-stellar contestants. It was the only singing competition of its kind at the time.

But last year Lopez, Tyler and lone original judge Randy Jackson seemed reluctant to point out contestants' shortcomings in the same blunt manner that helped make "Idol" must-see entertainment.

The TV landscape has also changed. "Idol" now faces challenges from NBC's competition "The Voice," and Fox's "The X Factor," which stars Cowell.

The show has helped launched the careers of pop stars Clarkson, Jennifer Hudson, Chris Daughtry and Carrie Underwood.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-01-18-American%20Idol/id-a981b50cd9224105a15bc6cd63a732d1

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Hospital chief: Brooks discussed $15 million gift (AP)

CLAREMORE, Okla. ? An Oklahoma hospital executive testified Thursday that country singer Garth Brooks considered donating as much as $15 million to the facility if it would rename itself after his late mother.

Brooks is suing the Integris Canadian Valley Regional Hospital in Yukon, saying it would not name a women's center for Colleen Brooks after receiving $500,000 from him. Colleen Brooks died of cancer in 1999. The center never was built.

Hospital president and CEO James Moore testified Thursday that discussions initially involved a much larger gift, The Tulsa World (http://bit.ly/Avdi1z) reported.

An internal document from the hospital quotes Brooks as saying a $15 million gift for naming rights was "exactly" what he had in mind.

Moore denied ever making a verbal agreement with Brooks on naming the proposed women's health center after his mother in exchange for the $500,000 donation. Moore said that gift from Brooks was anonymous and "unrestricted," meaning Integris could use the money at its discretion.

Brooks donated the money anonymously in December 2005, and Integris confirmed it was from him shortly afterward.

Under cross examination, Moore acknowledged he did promise Brooks he would do something to honor his mother, but maintained there was no agreement about naming a center.

Source: http://us.rd.yahoo.com/dailynews/rss/music/*http%3A//news.yahoo.com/s/ap/20120120/ap_en_mu/us_people_garth_brooks

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Thursday, January 19, 2012

Andrew Luck's uncle to serve as QB's agent

(AP) ? Andrew Luck's uncle will serve as the agent for the former Stanford quarterback and two-time Heisman Trophy runner-up.

The Wasserman Media Group announced Tuesday that Luck is the first and only NFL-bound player to sign with the agency. The company hired Luck's uncle, Will Wilson, as executive vice president of football to represent the quarterback.

Luck is expected to be the top pick in April's NFL draft after leading Stanford to consecutive BCS bowl games and shattering almost every major school passing record. The Indianapolis Colts hold the No. 1 pick.

Wilson spent the past four years as an executive for Major League Soccer and Soccer United Marketing. He also served in executive roles with the Arena Football League, Champ Car World Series and for 13 years with NFL International, including stops as managing director of NFL Mexico and general manager of the Scottish Claymores of NFL Europe.

"We are pleased to join forces with Will to maximize Andrew's potential in the sport of football," said Mike Watts, chief operations officer of Wasserman Media Group. "Will's more than 20 years of global sports business experience with some of the most successful leagues will also further our business strategies as we continue to expand internationally."

Luck declined comment through his father, Oliver, the West Virginia athletic director and former NFL quarterback, in a text message to The Associated Press on Tuesday. Wilson also will work with Wasserman's soccer division and its management team on international business development.

"Wasserman Media Group has an industry reputation second to none and a tremendous wealth of experience in athlete representation," Wilson said in a statement. "And as the agency's first, and only NFL player, Andrew will be receiving an outstanding service as he launches his career. I am also excited to help grow the agency's global business offerings."

After a record-setting season at Stanford, Luck is taking a break from football at the moment. He is on schedule to earn his degree in architectural design from Stanford in the spring and he will enter the draft as the most sough-after prospect since Peyton Manning in 1998.

Fittingly, Luck seems headed to Indianapolis.

He won the Maxwell Award as the college football player of the year and the Walter Camp Football Foundation Player of the Year. Despite so many pro scouts salivating over his potential, a three-turnover performance in a home loss to Oregon likely cost Luck the Heisman for the second straight season.

He finished as runner-up to Baylor's Robert Griffin III this season and to Auburn's Cam Newton a year earlier. While Griffin took home the bronze statue, Luck should take home the big bucks.

Luck leaves Stanford as the school's leader in touchdown passes (82), completion percentage (.670), passing efficiency (162.8) and total offense (10,411) ? among other marks ? despite playing only three seasons. A year after rolling past Virginia Tech 40-12 in the Orange Bowl, Luck didn't quite have the finish he had hoped. Stanford lost 41-38 in overtime to Oklahoma State in the Fiesta Bowl.

Stanford was ranked seventh in the final AP poll.

___

Follow Antonio Gonzalez at: www.twitter.com/agonzalezAP

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-01-17-FBN-NFL-Draft-Luck/id-bca85373653b40d58f3a492a6a1abab2

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